Encarnacion had offseason surgery on his left wrist, and aggravated the repaired appendage diving for a ball in Oakland last week.
The 27-year old took batting practice both Sunday and Monday, citing no serious pain. He has been taking anti-inflammatory medication to reduce lingering swelling.
"It feels good," Encarnacion said. "I'm looking forward to playing today. That's what I wanted -- to make sure I don't come back and play too soon. We have one month left and I don't want to hurt it again. I want to finish the season strong.
Blue Jays second baseman Aaron Hill also returned to the lineup Monday after a scheduled off-day in Boston. The struggling Hill batted just .167 through eight games on the Jays' recent road trip.