Escobar missed seven consecutive games starting Aug. 29 with a stiff back, but he had been taking batting practice.
Lewis has not played since he hyperextended his right elbow during his nine-pitch at-bat in the sixth inning Wednesday against the Rays.
Lewis has been available only for pinch-running duties since the injury, but he was not used in that capacity in the three games in New York.
"Fred's day-to-day, month-to-month," manager Cito Gaston said before Monday's game. "He's got a hyperextended elbow. I don't know what's going to happen there."
Escobar's last appearance was on Aug. 28, when he went 2-for-4 and scored two runs in a 5-4 win over the Tigers. He was back in his familiar No. 2 spot in the batting order for Monday's game.