Shortstop Adeiny Hechavarria, catcher Brian Jeroloman, outfielder Moises Sierra, and pitchers Josh Roenicke, Luis Perez and Robert Ray were sent down to the Minor League camp.
Toronto now has 26 pitchers, four catchers, 10 infielders and eight outfielders left.
Hechavarria is one of the club's top prospects, but needs more time to develop before he will be able to make the jump to the Major Leagues. The 21-year-old, considered a plus defender, hit .273 with three home runs and 34 RBIs in Double-A New Hampshire last year.
Jeroloman will be a prime candidate to get called up to the Major Leagues if either J.P. Arencibia or Jose Molina suffer injuries during the season. He likely will begin the year as the starting catcher in Triple-A Las Vegas. Last year, he hit .261 with seven home runs and 33 RBIs.
Roenicke, the only pitcher who entered camp with a chance to make the Blue Jays' Opening Day roster, was still considered to be a long shot. The 28-year-old went 1-0 with a 5.68 ERA in 16 games with Toronto last season.