Escobar is hitting just .069 (2-for-29) with 10 strikeouts and no extra-base hits in his previous seven games.
"It was a planned off-day to take advantage of the two days down," said Blue Jays manager John Farrell, whose team has an off-day looming on Monday.
"He has been going regularly for quite a long time, and just by watching some of the swings he could use a day down. He'll regenerate and be ready to go Tuesday when we get back home."
Escobar has played in 116 of the Blue Jays' 127 games this season. The Cuba native is batting .287 with 10 home runs and 41 RBIs.
John McDonald got the start at shortstop on Sunday, while second baseman Aaron Hill moved up in the order to fill Escobar's leadoff spot.