That gave Gose seven stolen bases for the spring, including four in Thursday's game.
"I never saw anybody steal second, third and home in the same inning in my career," said Blue Jays manager John Farrell, who arrived in the big leagues in 1987. "He is obviously exciting. He can take over on the basepaths. He has a combination of pure speed, plus the ability to read some things. You just turn him lose. He's a pure basestealer."
Gose, who stole 70 bases at Double-A New Hampshire last season while getting caught just 15 times, is slated to begin this season at Triple-A.
As for Thursday's steal of home, Farrell explained Gose saw Red Sox catcher Jarrod Saltalamacchia "lobbing the ball back" to reliever Justin Thomas and took off.
"It's a risky play," Farrell admitted, "but with two outs, it was a calculated gamble."
Drew Hutchison made the start for Toronto, holding Boston to four hits and a run over four innings.
Alfredo Aceves fired six strong innings in his latest audition to crack the starting rotation, allowing three hits and two runs -- one earned -- while walking two and striking out four. He threw 87 pitches, 54 for strikes.
"I feel good," said Aceves. "My body is getting used to the rhythm, the tempo of the game."
Ryan Sweeney drilled an opposite-field RBI double to give the Red Sox the lead in the bottom of the second. David Ortiz put one over the Monster for a solo shot in the sixth to tie the game at 2.
Eric Thames drilled a two-run single against Aceves in the sixth to put the Blue Jays on the board.
Up next: The No. 5 spot in the Blue Jays' rotation may be on the line Friday, when lefty Aaron Laffey (2-0, 4.80 ERA) takes the mound in Dunedin at 1:05 p.m. ET against also unbeaten Liam Hendricks (2-0, 2.40) of the Twins.
Prior to Thursday's game, Blue Jays manager John Farrell said the club "should have a better read" on the No. 5 starter after Friday's game and may make a decision on Saturday.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. Jim Hawkins, a contributor to MLB.com, added to this report. This story was not subject to the approval of Major League Baseball or its clubs.