Bautista hit a two-out blast to left field in the sixth inning against Minnesota's P.J. Walters. The original call was that the ball stayed in the field of play, but after viewing the replay, crew chief Tim Tschida signaled a home run that put Toronto ahead, 2-1.
The review was the first this year and 11th in two-plus seasons at Target Field. Five of those 11 calls have been overturned.
"I was hoping it didn't get out," Walters said. "I didn't hear anything from the metal ... but obviously they went in and came out pretty quick, so it was pretty clear."
Patrick Donnelly is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.