Farrell said Romero would be followed by Aaron Laffey, Carlos Villanueva, Henderson Alvarez and Brett Cecil, respectively.
"That takes into account the additional four days of rest that every starter's going to get -- and probably build in a couple of more for Henderson, just given what he's come through in [his] first full year [in] the Major Leagues," Farrell said. "He's on a pace to throw 200 innings."
Starting the series out of the break with two southpaws against the Indians is part of Farrell's design.
"Cleveland is a predominantly left-handed-hitting lineup," Farrell said. "The series that follows that, you're just trying to map out the matchups that might be in our favor."