First, third baseman Brett Lawrie left the game after the top of the first inning with tightness in his rib cage, an injury stemming from a fall he took in Toronto's series against the Yankees in mid-July, according to manager John Farrell.
After experiencing discomfort in one of his swings when leading off the game, Lawrie was removed and replaced by Omar Vizquel when the Blue Jays took the field in the bottom of the first. The injury added to what's already been a tough road trip for the 22-year-old -- he's gone 3-for-18 in the first five games of the trip.
Later, center fielder Colby Rasmus was taken out after the top of the 12th inning due to a strained groin, which Farrell said Rasmus actually suffered a couple innings prior.
Both players are day-to-day, and aren't expected to be in the lineup for Saturday's game against the A's.
Ben Estes is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.