Encarnacion did not play Thursday because of a stiff left shoulder and forearm, the result of a tumble he took on an attempted catch while playing left field in Wednesday's 9-5 loss to the White Sox. He grabbed his shoulder after the play but finished the game.
The 29-year-old slugger passed the final test before playing when he went through regular batting practice before Friday's game. He was in the third spot in the batting order and belted a two-run homer in his first at-bat of the game.
"Eddie took some soft toss and tee work in the cage," manager John Farrell said before Friday's game. "He felt good with that."
Encarnacion has started just two games in left field this season.
He entered Friday's game batting .293 with a career-high 30 homers and 80 RBIs.