The injury isn't expected to be serious, but it represents yet another blow to a Blue Jays team that is currently reeling because of health-related issues.
"He'll be all right," manager John Gibbons said. "I have no idea [if he can play on Wednesday]."
Izturis was the second Blue Jays player to go down with an injury on Tuesday. Right fielder Jose Bautista left with a bone bruise during Game 1 of the doubleheader and is expected to be out for at least the next two weeks.
Those two players join Toronto's list of walking wounded which now includes the likes of Josh Johnson, Steve Delabar, Brandon Morrow Juan Perez, Dustin McGowan, Melky Cabrera and Colby Rasmus.
It has been blow after blow over the past several weeks and the frustration has begun to take its toll inside of Toronto's clubhouse.
"I know all guys go through injuries, but this is starting to get a little ridiculous," starter Mark Buehrle said. "Guys are dropping like flies here. But this is why we play the season. I said that in Spring Training, obviously we look good on paper, but we have to go out there and stay healthy and when certain guys go down, you have to have certain guys step in.
"We're in a situation where we're not doing too good right now, a bunch of guys are falling down and getting hurt and we have to have guys fill in."
Izturis is hitting .236 with five homers and 31 RBIs in 106 games. That's just 16 games shy of a career high and the injury isn't expected to keep him out of Toronto's lineup for an extended period of time.
Gregor Chisholm is a reporter for MLB.com. Read his blog, North of the Border, and follow him on Twitter @gregorMLB. This story was not subject to the approval of Major League Baseball or its clubs.