The ankle swelled up overnight and was heavily wrapped prior to Toronto's 4-2 loss to the Yankees in New York on Wednesday night, which Izturis sat out.
Goins joins the Blue Jays after hitting .257 with 22 doubles, six home runs and 46 RBIs in 111 games for Buffalo this season. The 25-year-old left-handed hitter is in his fifth professional season after being selected in the fourth round of the 2009 First-Year Player Draft.
Veteran Mark DeRosa and fan favorite Munenori Kawasaki will split duties at second until Izturis can return.
"When Kawasaki threw me the ball, I couldn't jump, and I said, 'I can't play like that,'" Izturis said of why he left Tuesday night's game.
Izturis is hitting .236 with five homers and 31 RBIs in 106 games, which is just 16 games shy of a career high.
Gregor Chisholm is a reporter for MLB.com. Read his blog, North of the Border, and follow him on Twitter @gregorMLB. This story was not subject to the approval of Major League Baseball or its clubs.