Santos threw just eight pitches and allowed one hit against the Baysox, but it was a home run. He also struck out one.
"He felt good," Toronto manager John Gibbons said. "We're going to keep him down there, at least go another outing."
Santos allowed three earned runs on three hits and two walks during his first rehab outing for the Fisher Cats, while striking out two. He had a 9.00 ERA and five saves in 14 appearances with the Blue Jays before going on the DL.
Gibbons said he isn't sure where the next destination is for the righty, but Santos needs to get some more work in before returning to the Majors. A return isn't dependent on the results, but the team still needs to see him get back to where he's capable of pitching at a Major League level.
"We just want to build him up and sharpen him up," Gibbons said.
David Wilson is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.