Lawrie sustained the injury on Aug. 5 after returning from a six-week absence with a fractured right index finger. He played three innings before he was removed with the oblique issue that popped up during batting practice.
"He won't be coming back," manager John Gibbons said. "There's just not enough time. Where he's at, trying to build up ... he's not ready. He admitted that, but he doesn't like being inactive, that's for sure."
It's a bitter end to what had been a frustrating season for Lawrie. He struggled with the bat coming out of Spring Training and while there were signs of a turnaround, his overall health didn't comply.
Lawrie played in 70 games, which is his fewest number since he was promoted as a rookie midway through the 2011 season. The native of Langley, British Columbia, has dealt with a wide variety of injuries over the past three years, including to his ankle, hamstring and back.
"We waited as long as we could," general manager Alex Anthopoulos said. "He's improved. I talked to him [Monday] night and he's feeling better, but he's still feeling it a little bit and as we all know with respect to obliques, that needs to completely heal, and he has to not feel a thing before you ramp up baseball activity."
Gregor Chisholm is a reporter for MLB.com. Read his blog, North of the Border, and follow him on Twitter @gregorMLB. This story was not subject to the approval of Major League Baseball or its clubs.